Enlighten Imaging

XMAS – Cross-Modality Annotation Software

A smarter way to annotate retinal images.

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XMAS brings each patient's retinal images together in one window, aligns them, and lets a team annotate, measure and export across all of them. Made for researchers, clinicians and AI developers, and used in the published studies below. For research use only.

Why XMAS?

Every image, side by side

Colour fundus, autofluorescence and other photographs, hyperspectral images, OCT volumes (Heidelberg Spectralis, Zeiss) and MAIA microperimetry in synchronised viewers, each B-scan linked to its place on the en-face image.

Automatic image alignment

Coregistration aligns a patient's images onto one reference and scores each result for review. Where it falls short, align by hand with landmarks.

Annotation tools

Paint, pen, shapes, points and landmarks, B-scan layer segmentation, a smart brush that follows the image, and an AI brush that runs deep-learning models.

Grids and measurements

Sector grids with per-sector statistics, the MAIA grid, a measure tool, and the spectrum of any hyperspectral pixel.

Built for teams

Several people annotate one shared project at once. Comment on any annotation, and see every change with who made it and when.

Analysis-ready exports

Label masks, CSV coordinates and a manifest for statistics or model training, aligned images for a new project, and snapshots for figures.

Get started

  1. Download XMAS for Windows 10 or later and install it.
  2. Get a licence file: a free trial, or buy a licence below.
  3. Open XMAS and choose the licence file when it asks for one.

Free trial

Free

7 days, 1 seat, exports marked TRIAL

Your licence arrives by email in a minute. No account, no credit card.

Request a free trial

Academic

For universities and non-profit research, for non-commercial use. One-year licence, every feature, delivered by email once paid. Ask us for a price.

  • 1 seat
    Price on request     Ask
  • 5 seats
    Price on request     Ask

More than 10 seats? Request a quote, paid by invoice.

Commercial

For companies, hospitals, CROs and pharma. One-year licence, every feature, delivered by email once paid. Ask us for a price.

  • 1 seat
    Price on request     Ask
  • 5 seats
    Price on request     Ask

More than 10 seats? Request a quote, paid by invoice.

Used in Leading Research

  1. Saeed A, Guymer RH, Hadoux X, Jannaud M, Dang D, Hodgson LAB, et al. Customized Evaluation of Progressive Visual Sensitivity Loss in Geographic Atrophy to Improve the Power of Clinical Trials. Ophthalmol Sci. 2025;5(4):100763.
  2. Wu Z, Hadoux X, Jannaud M, Glover EK, Gee EE, Hodgson LAB, et al. Visual Sensitivity Loss in Geographic Atrophy: Structure-Function Evaluation Using Defect-Mapping Microperimetry. Invest Ophthalmol Vis Sci. 2024;65(1):36.
  3. Saeed A, Guymer RH, Hadoux X, Jannaud M, Dang D, Hodgson LAB, et al. Longitudinal Changes of Visual Sensitivity With Geographic Atrophy Progression Assessed by Defect-Mapping Microperimetry. Invest Ophthalmol Vis Sci. 2024;65(14):13.
  4. Kumar H, Guymer RH, Hodgson LAB, Hadoux X, Jannaud M, van Wijngaarden P, et al. Reticular Pseudodrusen: Impact of Their Presence and Extent on Local Rod Function in Age-Related Macular Degeneration. Ophthalmol Sci. 2024;4(6):100551.
  5. Greig EC, Moult EM, Despotovic IN, Hodgson LAB, Pramil V, Fujimoto JG, et al. Assessment of Choriocapillaris Flow Prior to Nascent Geographic Atrophy Development Using Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2024;65(1):33.
  6. Goh KL, Wintergerst MWM, Abbott CJ, Hadoux X, Jannaud M, Kumar H, et al. Hyperreflective Foci Not Seen as Hyperpigmentary Abnormalities on Color Fundus Photographs in Age-Related Macular Degeneration. Retina. 2024;44(2):214-21.
  7. Goh KL, Kumar H, Hadoux X, Jannaud M, Abbott C, Hodgson L, et al. Hyperpigmentary abnormalities in age-related macular degeneration: association with progression and impact on visual sensitivity. Br J Ophthalmol. 2024;108(2):263-7.
  8. Wu Z, Zhou X, Chu Z, Gregori G, Wang RK, Rosenfeld PJ, Guymer RH. Impact of Reticular Pseudodrusen on Choriocapillaris Flow Deficits and Choroidal Structure on Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2022;63(12):1.
  9. Goh KL, Abbott CJ, Hadoux X, Jannaud M, Hodgson LAB, van Wijngaarden P, et al. Hyporeflective Cores within Drusen: Association with Progression of Age-Related Macular Degeneration and Impact on Visual Sensitivity. Ophthalmol Retina. 2022;6(4):284-90.